Cancer is the leading cause of death worldwide with 8.2 million cancer related deaths in 2012 estimated by World Health Organization (WHO). PARP inhibitors breast cancer are the drugs, which inhibit the enzyme called poly ADP ribose polymerase (PARP). PARP inhibitors breast cancer developed for treating several diseases, the most important one is cancer. As several types of cancers rely on PARP than regular cells, which makes it attractive target for treating cancers. These PARP inhibitors breast cancer used to treat subset of ovarian cancer. Currently only PARP inhibitors breast cancer approved in the market is Lynparza from AstraZeneca and several PARP inhibitors breast cancer are in late stage pipeline which are showing promising results in the recent released clinical trials data. The first PARP inhibitor from AstraZeneca approved in late 2014 and market witnessed significant gain in 2015. PARP inhibitors breast cancer mainly indicated in few set of patients based molecular diagnostics. Several positive end points for these drugs are prolonged Progression Free Survival (PFS) and over survival rates.
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